| abstract |
(57) [Summary] [Structure] 3-Hydroxymethyl-6-methoxy-8- Angiogenesis inhibitor containing hydroxy-1H-2-benzopyran-1-one as an active ingredient [Effect] The present compound has a concentration of 0.01 to 0.1 mM, compared with the inhibitory effect on the growth of vascular endothelial cells. Since it has an action of particularly strongly inhibiting the tube formation of cells, various diseases in which angiogenesis plays an important role, that is, diabetic retinopathy, various chronic inflammation, psoriasis, angiogenesis associated with corneal transplantation, Furthermore, it is expected to be applied to the prevention and treatment of arteriosclerosis. |