| abstract |
(57) Abstract: A compound useful for the treatment of various diseases related to estrogen-dependent diseases including postmenopausal syndrome and cancer of breast, uterus and cervix, and a pharmaceutical composition containing the compound. Offer. SOLUTION: Formula (I): [Wherein R 1 and R 2 are optionally H, OH, halo, O PO (Oalkyl) 2 , OPO (Oaryl) 2 , OPO (Alkyl) 2, OPO (aryl) 2, or an OPO 3 -2, wherein one most in R 1 and R 2, H, O H, or halo, R 3 and R 4 are optionally CO (CH 2 ) 3 , CO (CH 2 ) 4 , alkyl, or R 3 and R 4 together with the nitrogen atom to which they are attached are piperidine, morpholine, pyrrolidine, 3-methylpyrrolidine, 3,3- Dimethylpyrrolidine, 3,4-dimethylpyrrolidine, azepine or pipecoline is formed] and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing them. |