| abstract |
(57) [Summary] (Correction) [Solution] General formula I: Or a pharmaceutically acceptable salt, ester or amide thereof, a pharmaceutical composition containing the same, and a composition containing the present compound and a retinoid having RARĪ± activity. Specific examples of compounds of general formula I include: (2E, 4E, 6Z, 8E) -3,6,7-Trimethyl-9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenoic acid Highly selective for the RXR family of receptors, useful as an antiproliferative agent in dermatological and oncological indications, and potentiating the retinoid activity of compounds having RARĪ± activity at doses which are themselves inactive Therefore, it is useful as an enhancer in the treatment of useful indications of retinoids. |