| abstract |
(57) [Summary] [Structure] A sulfonic acid amide derivative represented by the formula (I), a cyclodextrin clathrate compound thereof, or a salt thereof [in the formula, R 1 is (i) COOR 11 and (ii) CH 2 OR 12 Or (iii) CONR 13 R 14 ; R 11 is a carbocycle or steroid group optionally substituted with H, alkyl, lower alkyl, alkoxy or halogen; R 12 is H or COR 15 ; R 13 and R 14 are each H, lower alkyl or NR 13 R 14 which is an amino acid residue or a heterocycle; R 15 is a lower alkyl or phenyl group, Tx ring group moiety is a group of formula (C); Lc is a lower alkylene Group; R 2c is H, lower alkyl or halogen; the double bond between C 5 and C 6 in formula (C) represents cis or trans. ] [Chemical 1] The sulfonic acid amide derivative of the formula (I) is TXA 2 has an antagonistic effect and is caused by TXA 2 (inflammation, hypertension, thrombosis, stroke, asthma, myocardial infarction, angina, It is useful for the prevention and / or treatment of cerebral infarction, acute cardiac death, etc. |