| abstract |
(57) Abstract: [PROBLEMS] To provide a method for producing a sustained-release preparation, which allows easy and good yield of a sustained-release preparation containing peptide [I] or a salt thereof. SOLUTION: Formula [Wherein X represents hydrogen or tetrahydrofurylcarboxamide, Q represents hydrogen or methyl, A represents nicotinoyl or N, N'-diethylamidino, and B represents isopropyl or N, N'-diethylamidino]. A liquid containing a physiologically active peptide or salt thereof as an internal aqueous phase, A W / O type emulsion containing a solution containing a biodegradable polymer having a free carboxyl group at the terminal as an oil phase is produced, Next, a method for producing a sustained-release preparation, which comprises adding the obtained emulsion to an external water phase to produce a W / O / W type emulsion. [Effect] According to the production method of the present invention, a sustained-release preparation containing peptide [I] or a salt thereof can be easily obtained in good yield. |