| abstract |
(57) [Summary] (Modified) [Purpose] To provide a cholecystokinin (CCK) antagonist. [Structure] Formula (I) [Wherein, ring A is a benzene ring which may be substituted or an aromatic heterocycle which may be substituted, is represented by R 1 , R 2 and R 3 is hydrogen or an optionally substituted hydrocarbon group, X is a bond or a divalent atom chain, and ring B is an optionally substituted phenyl group or an optionally substituted aromatic heterocyclic group. , Z represents O or S (O) q (q represents 0, 1 or 2)] or a pharmaceutically acceptable salt thereof, which is a cholecystokinin antagonist. [Effect] A cholecystokinin antagonist containing a compound of formula (I) is anxiety, psychosis, appetite control disorder, intestinal smooth muscle dysfunction, pancreatitis, gallbladder disorder, gastric ulcer, duodenal ulcer, gastritis, reflux esophagus Flame, Zollinger Ellison (Zol It is useful for the prevention and treatment of Linger-Ellison) syndrome, pain, and various symptoms associated with gastrin induction. |