abstract |
(57) Abstract: (Modified) PROBLEM TO BE SOLVED: To provide a substituted thiophenesulfonylurea and thiourea having a pharmacological effect on the cardiovascular system. SOLUTION: The following formula I Wherein R (1) is hydrogen, halogen, alkyl having 1 or 2 carbon atoms, alkoxy having 1 or 2 carbon atoms, mercaptoalkyl having 1 or 2 carbon atoms, 1 or 2 A fluoroalkoxy having 1 carbon atom, and a fluoroalkyl having 1 or 2 carbon atoms: R (2) is hydrogen, methyl or trifluoromethyl: X is oxygen (compound Ia) or sulfur ( Compound Ib): Y and Z are the same or different and are hydrogen, F, Cl, Br, I, alkyl having 1 or 2 carbon atoms, and alkoxy having 1 or 2 carbon atoms). Substituted thiophenesulfonylurea or thiophenesulfonylthiourea. |