| abstract |
(57) Abstract: An immunogen in the form of a benzodiazepine-protein conjugate capable of producing an antibody having high cross-reactivity to various benzodiazepines, particularly urinary benzodiazepine metabolites. Formula I: Wherein R 1 is hydrogen, methyl or R group, R 2 is hydrogen, hydroxyl or OR group, wherein either R 1 or R 2 contains R group, R 3 is halogen, NO 2 Or NH 2 , X is hydrogen or halogen, R is of formula II: [Wherein Z is a carrier of a macromolecule that is active as an immunogen, and n is 2 or 3], and the benzodiazepine-protein conjugate is an immunity for obtaining an antibody against benzodiazepine. It can be used as a raw material. |