| abstract |
(57) [Summary] (Modified) [Objective] To provide a simple method for producing a 3-cephem compound with high yield and high purity. [Structure] The 3-halomethylcephem compound represented by the general formula (1) is reacted with the general formula (2) in the presence of metallic copper or a copper compound. A method for producing a 3-cephem compound represented by the general formula (3), which comprises reacting with an alkenyl compound represented by: [Wherein R 1 represents a hydrogen atom or a (protected) amino group, R 2 is a hydrogen atom, a halogen atom, a lower alkoxy group, a lower acyl group, or a lower alkyl group having a (protected) hydroxyl group as a substituent, R 3 is a hydrogen atom or a carboxylic acid protecting group, and R 4 is a substituent. A 1-alkenyl group which may have a group, X is a halogen atom, Z is a halogen atom or a lower alkyltin group, and n is 0 or 1 Is] |