| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95eaed79dec59391549e8016815b3a8f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-52 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate |
1995-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d2b7d082b049b490d341ebc68f5fa4f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_690107979b8e685cad2b651098310678
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_021b23a7e28ff22220542da2c779a295
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a19d6586488f85e4cc127a59df01f5f9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a2f421fa68dacfbdb6f8705a2148e6d |
| publicationDate |
1996-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-H08231599-A |
| titleOfInvention |
Anti-tyrosinase monoclonal antibody Fab fragment |
| abstract |
(57) [Summary] [Object] To provide a Fab fragment in which an Fc portion that binds to macrophages and the like is removed from an anti-human tyrosinase antibody. [Structure] The Fab fragment is obtained by the following steps. (A) After immunizing a mammal with a conjugate of a carrier and a peptide having at least a part of the amino acid sequence having a low homology with the amino acid sequence of a tyrosinase-related protein among the amino acid sequences of tyrosinase, the animal is immunized. Spleen cells are removed and fused with cultured cells to prepare a hybridoma, and (b) a hybridoma that produces a monoclonal antibody that binds to tyrosinase and does not bind to tyrosinase-related protein is selected, and (c) the hybridoma is appropriately selected. Antibody protein was collected from the culture supernatant obtained by culturing in a different medium, or ascites obtained by culturing the hybridoma in the abdominal cavity of a mouse, and (d) the antibody protein was partially digested with a protease to produce a Fab fragment and an Fc fragment. Cleave and cut the Fab fragment. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210018682-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021025239-A1 |
| priorityDate |
1995-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |