| abstract |
(57) [Summary] [Structure] [Chemical Formula 1] [R 1 and R 4 are a carboxyl group which may be converted to an ester, amide or hydroxamic acid, R 2 is a lower alkyl group or a phenyl lower alkyl group, R 3 is a hydrogen atom, a lower alkyl group, an amino lower alkyl group, Lower alkylamino lower alkyl group, hydroxy lower alkyl group, mercapto lower alkyl group, carboxy lower alkyl group, lower alkoxycarbonyl lower alkyl group, imidazolyl lower alkyl group, indolyl lower alkyl group, A (substituted) phenyl group, a (substituted) phenyl lower alkyl group, a (substituted) naphthyl group or a (substituted) naphthyl lower alkyl group] and salts thereof. [Effect] The compound of the present invention is endopeptidase 24.1. 1, which has an inhibitory activity against 1, cardiovascular diseases such as heart failure and hypertension, renal diseases such as renal failure, diarrhea, gastrointestinal disorders such as excessive gastric acid, endocrine / metabolic diseases such as obesity, and autoimmune diseases such as rheumatism It is useful as a therapeutic agent for the above and an analgesic for myalgia, migraine and the like. |