| abstract |
(57) [Summary] [Chemical 1] Embedded image [Objective] To provide an antitumor cycloalkaneamine derivative platinum (IV) complex having further antitumor activity and aiming at simpler oral administration. ## STR1 ## Formula 1 wherein R is a C 5 to C 7 cycloalkane, X is one selected from bromine, iodine, fluorine, hydroxy or carboxylate, and Formula 2 is chlorine or platinum (IV ) Is a ligand that forms an O, O-coordinated 5- or 6-membered ring)). It is highly lipophilic and has an excellent antitumor effect. |