| abstract |
(57) [Summary] [Objective] An N-alkyl derivative is selectively and efficiently produced from a cyclic amide compound. A method for producing an N-alkyl derivative, which comprises reacting a cyclic amide compound with an alkyl halide derivative in an inert ether solvent using cesium carbonate as a catalyst. [Effect] With an N selectivity of 90% or more, an N-alkyl derivative can be obtained in high yield. Therefore, a compound that crystallizes, such as a biphenyl derivative, can greatly omit the separation and purification process after the reaction, which is industrially advantageous. |