| abstract |
(57) [Summary] [Structure] 281 produced by mouse bone marrow stromal cells Amino acid polypeptide, human homologue thereof, method for producing the same, DN encoding the polypeptide A, a fragment that selectively hybridizes to the DNA sequence, a replication or expression vector comprising the DNA, A host cell transformed with the vector, an antibody of the polypeptide, and a pharmaceutical composition containing the peptide or antibody. [Effects] The polypeptide of the present invention is used for the developmental failure or abnormal proliferation of hematopoietic cells, the diseases related to the increase or decrease of nervous system function, the increase or decrease of immune system function, for example, inflammatory disease or hematopoietic stem cells after bone marrow transplantation. Reduction, reduction of white blood cells, platelets, B cells or T cells after radiation treatment, prevention or treatment of anemia or infection, prevention or treatment of cancer, leukemia or AIDS, It can be used for various degenerative diseases, prevention or treatment of nerve damage, prevention or treatment of abnormal bone metabolism, tissue repair and the like. |