| abstract |
(57) [Abstract] (Corrected) [Problem] 2-Aryl-6-hydroxy-3- [4- Provided is a novel method for producing (2-aminoethoxy) benzoyl] benzo [b] thiophene. SOLUTION: The following formula I [Wherein R 1 is hydrogen or hydroxyl, R 2 and R 3 Are independently C 1 -C 4 -alkyl, or R 2 and R 3 together with adjacent nitrogen atoms form a heterocyclic group selected from the group consisting of pyrrolidino, piperidino, hexamethyleneimino and morpholino, HX is HCl Or HBr], which is a method for producing a crystalline solvate of a compound represented by the formula (II): The benzothiophene represented by One or more phenolic groups of the acylation product of step (a) by reacting with an additional BX ' 3 which is acylated in the presence of BX' 3 with an acylating agent represented by Dealkylating the compound, and (c) isolating the crystalline solvate. |