| abstract |
(57) [Summary] (Modified) [Purpose] A novel 8-trifluoromethylquinolinecarboxylic acid derivative that inhibits the growth of human immunodeficiency virus, Alternatively, a pharmaceutically acceptable salt or ester thereof is provided. [Structure] The following general formula (I): (In the formula, R 1 represents a lower alkyl group, a halogeno-lower alkyl group or a cycloalkyl group, R 2 is a phenyl group which may be substituted with R 0, which may be substituted with R 0 N, O and A 5-membered or 6-membered heteroaromatic monocyclic group containing 1 or 2 heteroatoms selected from S or a heteroaromatic condensed ring in which these heteroaromatic monocycles and a benzene ring are condensed, and R 0 is halogen or lower alkyl , A fluorine-substituted lower alkyl, a lower alkoxy or a lower alkylthio, R 3 represents a hydrogen or a lower alkyl group, and m represents an integer of 2 or 3. A trifluoromethylquinolinecarboxylic acid derivative or a pharmacologically acceptable salt or ester thereof. |