| abstract |
(57) [Summary] [Purpose] When applied externally to the skin, oxidized CoA or its salt, which has a physiological effect, efficiently penetrates the stratum corneum barrier and activates keratinocytes, fibroblasts, etc., It is intended to provide a skin external preparation composition exhibiting an excellent effect of preventing skin aging. [Structure] [A] Oxidized CoA and / or salt thereof, [B] A polyhydric alcohol having two hydroxyl groups in the molecule, A skin external preparation composition containing [C] a nonionic surfactant having HLB in the range of 3 to 19 and [D] a fatty acid ester having 8 to 40 carbon atoms. |