http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H08143519-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e7b522b71fd001f1a633fd8563b2a3e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 |
| filingDate | 1994-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_78653376179fcf421e7ddd8931c23919 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04eb35c8917b3348b94f14167f126440 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27f483ec177954489aff8d6de6b86705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfde108990146875235fbe4909b448d8 |
| publicationDate | 1996-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H08143519-A |
| titleOfInvention | Method for producing fluorine-labeled radioisotope L-noradrenaline |
| abstract | (57) Abstract: OBJECTIVE 18 F- L-noradrenalin provide high yield and a manufacturing method of the 18 F- L-noradrenaline can be obtained in a short time. [Constitution] Isovanillin is nitrated to obtain 6-nitroisovanillin. An intermediate (II) is condensed by an ether bond with a crosslinked chloromethylstyrene-styrene copolymer carrier crosslinked with 6-nitroisovanillin and vinylbenzene. I) get Next, the nitro group of the intermediate (III) is converted into 18 F- Nucleophilic substitution with to give intermediate (IV). Then, the intermediate (IV) is reacted with cyanotrimethylsilane to obtain the intermediate (V). Then, the intermediate (V) is reduced to obtain the compound (VI), which is further subjected to a hydrolysis reaction to give 18 F-D, L. A racemic mixture of noradrenaline is obtained. Finally, racemic separation is performed to obtain 18 F-L-noradrenaline. Embedded image |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111019981-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102432442-A |
| priorityDate | 1994-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.