abstract |
(57) [Summary] [Constitution] The present invention comprises an activity of converting big endothelin into endothelin, which comprises the amino acid sequence of amino acid Nos. 1 to 758 in the amino acid sequence shown in SEQ ID No. 2 in the sequence listing. And the like. [Effect] According to the present invention, a large amount of human ECE can be obtained, which can be used for searching and evaluating ECE inhibitors. Furthermore, by using a transformant expressing human ECE or a part thereof as an immunogen, it becomes possible to produce ECE-specific antibodies, which can be applied to diagnosis of diseases such as myocardial infarction. |