| abstract |
(57) [Summary] [Structure] General formula [Chemical formula 1] [R 1 : 3-8 membered cyclic amino, mono or di (C 1- C 4 alkyl) amino; R 2: C 1 -C 6 alkyl, Harogeno C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 - C 6 cycloalkyl, C 6 -C 10 aryl, 5-6 membered cyclic heterocyclyl; A: C 3- which may have a double bond C 5 alkylene; B: single bond, the formula -NHCO-E- (E: C 1 -C 5 alkylene); D: single bond, C 1 -C 5 alkylene, provided that R 2 : C 1 -C 6 alkyl, halogeno C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C In the case of 3- C 6 alkynyl, D: a single bond] having a thiophene derivative or a pharmaceutically acceptable salt thereof. [Effect] The compounds excellent gastric acid secretion inhibitory action and antiulcer activity and H. pylori (Helicobacter p It has an antibacterial action against ylori ) and is useful as an anti-ulcer agent. |