| abstract |
(57) [Summary] (Modified) [Constitution] The compound of the formula (I) and a salt thereof. [In the formula, A is C 1-8 alkylene, etc .; B is a 5-7-membered monocyclic heterocycle containing 1-2 nitrogen atoms; G is hydroxy; C 1-4 alkoxy, di (C 1-4 alkyl) amino and the like; R 1 and R 2 are -D 1 -E 1 (wherein D 1 is a single bond, C 1-8 alkylene and the like, E 1 is hydroxy, C 1-4 alkoxy, Feniruami, C 1 to 6 alkoxycarbonyl, cyano, imidazolyl, substituted guanidino like; R 4, R 5 is a hydrogen atom, C 1 to 8 alkyl; - D 1 -E 1 etc., and n is an integer of 1 to 3] [Effect] TXA 2 synthase inhibition, 5-lipoxygenase inhibition, active oxygen scavenging action, thrombosis, arteriosclerosis, ischemic It is useful for prevention and / or treatment of heart and brain diseases, bronchial asthma, inflammatory kidney disease, rheumatism, arthritis and the like. |