| abstract |
(57) [Summary] [Structure] The D ring and the B moiety bonded thereto are (i) to (iv) Oxime derivative (I) and a salt thereof, a process for producing the same and a drug containing the same (in the formula, R 1 is H, lower alkyl; R 2 Is H, alkyl, phenyl, cycloalkyl, monocyclic ring containing N, benzene ring or cycloalkyl-substituted lower alkyl, monocyclic substituted lower alkyl containing N; R 3 is alkyl, Phenyl, cycloalkyl, monocyclic ring containing N, benzene ring or cycloalkyl group-substituted lower alkyl, monocyclic substituted lower alkyl containing N; e is 3 to 5, f is 1 to 3, p is 1 4, q is 1 to 2, r is 1 to 3; the bond to the D ring of (iii) or (iv) is at the a or b position, and the ring in R 2 and R 3 is a lower alkyl, alkoxy, It may be substituted with halogen, nitro or trihalomethyl. ). Embedded image [Effect] It has a PGI 2 receptor agonistic effect and is useful for the prevention and / or treatment of thrombosis, arteriosclerosis, ischemic heart disease, gastric ulcer, hypertension and the like. |