| abstract |
(57) [Summary] (Modified) [Structure] Biphenylmethylamine derivative represented by the formula [I] and a therapeutic agent for heart failure containing the same [In the formula, R 1 is hydrogen, a C 1 -C 6 -alkyl group, and C 3- A C 6 -cycloalkyl group or the like; R 2 is —COOH, —S O 3 H, a tetrazolyl group or the like; R 3 , R 4 is hydrogen, C 1 -C 6 - alkyl, C 3 -C 6 - cycloalkyl group, Phenyl group, - (CH 2) a m X like; Z is -CH = CH -CH = CH -, - N = CH-CH = a CH- like; X is F, Cl, Br, CN, No 2, -CH (CN) 2, - CH (COOMe) 2 , —CH (COOEt) 2 and the like; m represents 0, 1, 2; respectively] [Effect] This compound has angiotensin II antagonism and is highly safe and is used as an active ingredient of a preventive or therapeutic drug for congestive heart failure, chronic renal disease and the like. . |