| abstract |
(57) [Summary] [Objective] To provide a novel CEH / ACAT inhibitor. [Structure] Formula: (In the formula, p is 0 to 4; Z is an aryl group or a heteroaryl group; A is a saturated or unsaturated C 1-20 hydrocarbon straight chain or branched chain; R 1 , R 2 , R 3 , R 4 And R 5 each independently represent hydrogen, a C 1 -C 8 alkyl group or the like) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the compound as an active ingredient. [Effect] A novel triscarbamic acid ester that inhibits CEH and / or ACAT and reduces cholesterol absorption is obtained. A pharmaceutical composition containing this novel compound as an active ingredient is useful for treating diseases in which reduction of cholesterol absorption is desired, such as atherosclerosis, familial hypercholesterolemia, and hyperlipidemia. |