| abstract |
(57) [Summary] [Objective] To provide an antitumor agent having excellent effects. [Structure] Formula [Chemical Formula 1] [Wherein, A ring is a pyrrole or pyrroline ring, X is an amino group or a hydroxy group, Y is a hydrogen atom, an amino group or a hydroxy group, R is a hydrogen atom, a fluorine atom, an alkyl group, an alkenyl group or an alkynyl group, COOR 1 and- COOR 2 is the same or different and represents an optionally esterified carboxy group, n is an integer of 2 to 4, and R may be different in n repetitions. ] An antitumor agent comprising a fused pyrimidine derivative represented by the formula [I] and a type I antitumor compound in combination. [Effect] Synergistic effect of antitumor effect. |