| abstract |
(57) [Summary] [Structure] [Chemical Formula 1] [Wherein R is hydrogen, an alkyl or hydroxyl group having 1 to 4 carbon atoms, R 1 is an alkyl group having 1 to 12 carbon atoms, R 2 and R 3 are each hydrogen, optionally substituted with a hydroxyl group. Represents an alkyl group having 1 to 12 carbon atoms or an alkenyl group having 2 to 12 carbon atoms, or in combination with an adjacent nitrogen atom, optionally oxygen, sulfur or further one nitrogen atom (the latter May have a substituent of phenyl, benzyl or alkyl having 1 to 4 carbon atoms), R 4 and R 5 Are hydrogen, halogen, or 1 to 4 carbon atoms, respectively. Of the above, or a 3,4-methylenedioxy group together, n is an integer of 2 to 5, and A represents a bond by a valence or a group represented by —CH 2 —. Substituted cycloalkane derivatives, sterically or optically active isomers thereof and possible mixtures thereof, as well as acid addition salts and quaternary ammonium derivatives thereof. [Effect] The present compound has valuable anti-ulcer and gastric acid secretion inhibitory activities, and is useful as a therapeutic drug. |