| abstract |
(57) [Summary] (Modified) [Constitution] General formula (I) (In the formula, for example, R 1 , R 2 , R 3 , and R 4 each represent a hydrogen atom, R 6 and R 7 each represent a lower alkyl group which may have a substituent, and A represents a general formula ( II) (Wherein R 5 is, for example, a hydrogen atom), and n Represents an integer of 1 to 6. ) Or its possible stereoisomers, optical isomers and pharmaceutically acceptable salts thereof. [Effects] The compound represented by the general formula (I) has not only a vasorelaxant action (calcium antagonism) and a lipid peroxidation inhibitory action, but also a calcium overload inhibitory action, and is useful for preventing ischemic diseases. It is useful as a therapeutic agent and an antihypertensive agent. |