| abstract |
(57) [Summary] The present invention relates to a method for producing a monoclonal antibody against a growth factor receptor, which comprises using a solubilized product of human cancer cells as an immunogen, and a human breast cancer cell line SK-BR-3. And an anti-c-erbB-2 monoclonal antibody which reacts specifically with a c-erbB-2-related protein produced by a hybridoma formed by the fusion of immune cells of a mammal immunized with The present invention provides an antitumor agent and a diagnostic agent for cancer, which are contained as essential components. [Effect] The antibody of the present invention is characterized by specifically reacting with a c-erbB-2-related protein, and is useful for diagnosis and treatment of adenocarcinoma, particularly breast cancer. |