| abstract |
(57) [Summary] (Corrected) [Structure] General formula [Wherein R 1 represents a hydrogen atom or a hydroxyl group, and R 1 2 and R 3 represent a hydrogen atom or a cyano group (provided that R 2 and R 3 are different), and Ar is In the formula, X represents an oxygen atom or a sulfur atom. ] The (alpha), (beta) -diaryl acrylonitrile derivative shown by these. [Effect] The compound of the present invention has a strong and highly selective inhibitory effect on 12-lipoxygenase, It is useful as a drug for the prevention and treatment of various diseases of the circulatory system such as arteriosclerosis and vasospasm, and the prevention of metastasis of certain cancers, and has low toxicity and few side effects. |