| abstract |
(57) [Summary] [Purpose] Having a mercapto group at one end and another functional group at the other end, it is highly reactive with physiologically active substances such as proteins, and by binding to these substances, A novel and useful polyalkylene oxide derivative capable of imparting non-immunogenicity and hydrophilicity is obtained. [Structure] Ethylene oxide or propylene oxide was obtained by polymerizing with a polymerization initiator represented by R 2 -S - M + [R 2 is an acyl group, arylalkyl group, etc., M is an alkali metal]. R 2 -S- (C H 2 CH (R 1 ) O) n-A-X 2 [n is 5 to 10000, R 1 is H or a methyl group, A is an alkylene group, X 2 is a carboxyl group, an amino group or an aldehyde group] To obtain a polyalkylene oxide derivative represented by HS- (CH 2 CH (R 1 ) O) n-A-X 2 by hydrolyzing this intermediate in the presence of an acid or an alkali. . |