| abstract |
(57) [Summary] (Modified) [Objective] To provide a method for producing an optically active tri-substituted methane compound having an excellent pharmacological action. [Structure] An ortho or / and para-unsubstituted phenol compound and an optically active secondary carbinol compound having an α-position aromatic ring group in the presence of tri-substituted phosphine and diazodicarboxylate or diazodicarboxamide To produce an optically active tri-substituted methane compound of formula (I) having a phenyl group having a hydroxyl group as a substituent and an aromatic group. (In the formula, R 1 to R 4 represent H, a group that does not participate in the reaction, and even if adjacent two of them are bonded to each other to form a ring with a carbon atom on the benzene ring to which they are bonded. Often, Q represents an aromatic ring group and R represents a group that does not participate in the reaction.) |