| abstract |
(57) [Summary] [Structure] General formula: [Wherein R 1 represents a hydrogen atom; R 4 and R 5 each represent a hydrogen atom or an alkyl group; and R 8 represents a group. -CO-OR 15 (wherein R 15 represents a hydrogen atom or an alkyl group); and R 8 and X are in the meta or para position of the aromatic nucleus] and their unsaturated derivatives and Geometric isomers, optical isomers and salts thereof, And a pharmaceutical composition containing at least one of them. [Effect] It shows remarkable activity in local and systemic treatment of acne, psoriasis and other skin diseases or inflammatory and allergic skin infections, and further shows antitumor activity. |