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filingDate 1995-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73e563239bdff35ca0f9f6e208b41874
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publicationDate 1995-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H07311146-A
titleOfInvention Device and method for intracavity detection of macroscopic properties of drugs
abstract (57) [Abstract] [Purpose] To provide a method and an apparatus for detecting the presence of a target substance in a sample with a sensitivity higher than that of a conventional detection system. [Structure] Macroscopic characteristics and microscopic characteristics The properties and are used to detect the presence of trace amounts of material in sample 30. The detector includes a light source 25 and an optical resonator. The light source can be located either inside or outside the cavity of the optical resonator and can be a semiconductor such as a semiconductor laser or a superluminescent diode. The detector also comprises at least one reflecting member 24 having a total internal reflection surface 26, which can be a passive device or an active gain element. The light from the light source is preferably focused at a single reflection point on the total internal reflection surface. The test sample is placed in the attenuation field area of the total internal reflection surface. Optical changes that occur within the attenuation field are then detected, such as excitation of fluorescence in the sample, changes in its refractive index, and changes in the resonant frequency of the optical resonator. These changes are detected to determine the amount of analyte, or at least its presence, located on the total internal reflection surface.
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