| abstract |
(57) [Summary] (Correction) [Constitution] General formula (I): [In the formula, R 1 and R 2 are C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; R 3 is hydrogen or C 1 -C 6 alkyl; R 4 is halogen, C 1 -C 6 alkyl or C 1 -C 6 alkoxy; R 5 is C 1 -C 6 alkyl; X and Y are different CO or SO 2 with each other; n is 1, 2 or 3; p is 0 or 1; Z is, S, or O A is 2-azabicyclo [2.2.2] octane or the like, or -N (R 6) -CH (R 7) - (R 6, R 7 is hydrogen or C 1 -C 6 alkyl, etc.) (including the corresponding hydrates of the COCF 3) a is The compound represented by the , Its enantiomers, diastereomers or epimers, or its addition salts with an acceptable base. [Effect] The above compound has human leukocyte elastase inhibitory activity and antioxidant activity, and exhibits effects on degenerative diseases of connective tissue and inflammatory diseases. |