| abstract |
(57) [Summary] [Purpose] Activated specifically at the site of vascular endothelial cell damage, To provide a hepatic parenchymal growth factor derivative capable of targeting treatment of endothelial cells at a site of vascular injury by maintaining an inactive form at other sites. [Structure] The amino acid sequence of 492 to 494 from the N-terminus of the amino acid sequence of hepatocyte growth factor is Gl. n / Glu-Xaa-Arg (Gln is glutamine, G The hepatocyte growth factor derivative is substituted with lu for glutamic acid, Arg for arginine, and Xaa for glycine, serine, or threonine. |