| abstract |
(57) [Summary] [Structure] An intraocular pressure-lowering agent for eye drop and / or a therapeutic agent for glaucoma for eye drop, which comprises the following compounds, salts, esters and the like. [Chemical 1] [R 1 : alkyl, alkenyl, formula R 5 -AB- (R 5 : H, alkyl, cycloalkyl, acyl; A: O, S; B: single bond, an alkylene); R 2: alkyl, alkenyl, wherein -C (R 6) (R 7 ) (R 8) (R 6: O H, alkoxy; R 7, R 8: H , alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl); R 3: COOH, wherein -CON (R 9) (R 10 ) (R 9 , R 10 : H, substitutable alkyl); R 4 : COO H, COCOOH, tetrazole] |