| abstract |
(57) [Summary]n[Purpose] An amino group at one end and another at the other end A compound that has a functional group and is reactive with proteins Enriched in non-immunogens by binding to these substances And useful polyoxyal which can impart hydrophilicity and hydrophilicity The xylene derivative is selectively produced.n[Structure] Having a cyclic disilazane group as a polymerization initiator Polymerized ethylene oxide in the presence of amine derivatives After that, the obtained polymer is reacted with an electrophile, and one of the A protected group of the groups represented by X below is introduced at the terminal. Next, weak acid treatment is performed to convert the other end into an amino group, and Is protected by hydrolysis in the presence of acid or alkali. Group is converted to a group represented by X below, and H 2 N-Y-N (R)-(CH 2 CH 2 O) n-Y-X [Y is an alkylene group, R Is an alkyl group, X is a hydroxyl group, a carboxyl group, a mercap Group or aldehyde group, n is 5 to 10000] A polyoxyalkylene derivative is produced. |