| abstract |
(57) [Summary] [Structure] A novel membrane-bound polypeptide (PD-1) related to programmed cell death in human, DNA encoding the polypeptide, replication and expression vector comprising the DNA, and the vector. Transformed host cells, An antibody of the polypeptide, and a pharmaceutical composition containing the polypeptide or the antibody. [Effect] Human PD-1 can be used as a therapeutic agent for infectious diseases, decreased or increased immune function, tumors, and the like. The DNA encoding PD-1 is used as an essential template for producing PD-1, and the DNA or fragment thereof can be used to detect the PD-1 gene, and the gene and biological defense function, immune function, tumor It can be used for research on the relationship with diseases such as, and diagnosis of diseases. In addition, the PD-1 antibody can be used as a diagnostic or therapeutic agent for PD-1-related diseases. |