| abstract |
(57) [Summary] (Modified) [Objective] To provide a novel optionally substituted phenylimidazolidine, a method for producing them, and a pharmaceutical composition containing them. The compounds of the invention have the general formula (I). Wherein, Y represents O, S or NH; -A-B- is a group -C (= X) -N (R 3) - or a group -C (SR 3) = Selected from N-, where X is O or S, R 3 is H, C 1 -C 12 - alkyl, C 6 ~C 12 - aryl or the like; R 1, R 2 is -CN, -NO 2, -CF 3, -C OOH (including its ester and salt), a halogen atom; R 4 and R 5 are H or C 1 -C 12 -alkyl, or they are bonded to each other to form C 2 -C 6 -alkylene. EFFECTS The compounds of formula (I) have antiandrogenic activity and are used for the treatment of adenomas and neoplasia of the prostate and for the treatment of benign hypertrophy of the prostate. |