| abstract |
(57) [Summary] [Structure] General Formula (I) A novel compound AM5221 represented by the formula (wherein R represents a hydrogen atom or a methyl group) or a salt thereof, and a process for producing the same by a microorganism belonging to the genus Fiarocephala. [Effect] It exhibits an excellent NGF production promoting action, and for example, a therapeutic agent for Alzheimer-type senile dementia, a therapeutic agent for Huntington's chorea, a therapeutic agent for diabetic peripheral neuropathy, a therapeutic agent for peripheral nerve injury, a therapeutic agent for spinal cord injury and muscle atrophy. It is useful as a therapeutic agent for lateral sclerosis, an agent for improving brain metabolism or an agent for improving peripheral neuropathy. |