| abstract |
(57) [Summary] [Object] To provide a selective antagonist of the glycine binding site of the NMDA receptor. [Structure] A tricyclic quinoxalinedione derivative represented by the general formula 1 or a salt thereof. [Chemical 1] Wherein X is hydrogen, alkyl, halogen, cyano, trifluoromethyl or nitro; R 1 is hydrogen, alkyl, cycloalkyl or cycloalkylalkyl; G is the formula: -CONR 2 - or -NR 2 CO- (R 2 is hydrogen or alkyl); J is a group can be converted to an acidic group in the acidic or in vivo; E is converted to a basic group basic group or in vivo An obtainable group; Y is a single bond, alkylene, alkenylene, substituted alkylene, or the formula: Y 1 -Q-Y 2 (Y 1 is a single bond or alkylene, Y 2 is alkylene and Q is oxygen or sulfur); and Z is alkylene. . |