| abstract |
(57) [Summary] [Structure] A pyridine derivative represented by the following general formula (I). [Chemical 1] (In the above formulas, R 1 and R 2 represent a C 1-6 alkyl group, R 3 represents a hydrogen atom, a hydroxyl group, a C 1-6 alkoxy group or a phenyl C 1-4 alkoxy group, R 3 4 represents a hydrogen atom, C 1-6 alkyl, C 2-7 alkenyl group or C 2 -7 acyl group, A is the group -C It represents OOR 5 or a tetrazolyl group) [Effect] The above compound has angiotensin II antagonism, and has use as an antihypertensive agent and a therapeutic agent for heart failure which are effective in treating and preventing hypertension and heart failure. |