| abstract |
(57) [Summary] [Objective] To provide a therapeutic agent for myocardial reperfusion injury and myocardial stunning. A therapeutic agent containing a compound of formula (I), a salt thereof, or a solvate thereof: [X is H, F, Cl, Br, alkyl, cycloalkyl, alkoxy, alkylthio, CF 3 , alkylsulfonyl, nitro, phenyl, alkanoyl, benzoyl, etc .; Y is H, F, Cl, Br, alkyl, cycloalkyl, Alkoxy, alkylthio, CF 3 ; X and Y for methylenedioxy, etc .; X and Y for adjacent carbons And W is O, S; R 1 is alkyl, cycloalkyl, cycloalkenyl, phenyl, phenylalkyl, Phenoxyalkyl, thio phenoxyalkyl, naphthyl, - (CH 2) n- Q-R 0 or the like; n is 0, 1, 2; Q Is furan, thiophene, pyrrole, pyrazole, imidazole, thiazole, isothiazole, oxazole and the like; R 0 is H, F, Cl, Br, alkyl] |