| abstract |
(57) [Summary] (Modified) [Purpose] 6- (Polycyclic heterocyclic) -2- (lower alkyl) -3- showing activity as angiotensin II antagonist Provided (substituted) quinazolinone compounds. A quinazolinone compound having the formula I and a pharmaceutically acceptable salt thereof, a process for producing them, and an effective amount of the compound or a pharmaceutically acceptable salt thereof, hypertension or depressive heart attack. A pharmaceutical composition useful for the treatment of. [Wherein R is 1H-tetrazol-5-yl, carboxyl or -NHSO 2 CF 3 ; X is C 3 -C 5 It is alkyl; R 6 is -C (= CH 2) -COOR 7 (However, R 7 is H, CH 3 ) or a condensed complex such as hexahydropyrrolo [1,2-b] isoxazol-2-yl, tetrahydro-2H-isoxazolo [3,2-b] isoquinolin-2-yl, etc. It is a ring group] |