| abstract |
(57) [Summary] (Modified) [Purpose] Novel 1-phenyl-3-phenyl-2-propyn-1-ones, use of these compounds as inhibitors of calcium uptake in leukocytes and platelets , And their manufacturing methods. [Constitution] The following formula (1) [Wherein R 1 , R 2 and R 3 are each independently hydrogen, C 1- C 6 alkyl, C 1 -C 6 alkoxy, halogen, -N (Y 1 ) (Y 2 ), where Y 1 and Y 2 are each independently hydrogen or C 1 -C 6 alkyl, or X Z- (A r ') - (CH 2) n -0- ( wherein Ar' is phenyl or naphthyl, n = 0 or 1, X = C 1 - C 6 alkoxy or -N (Y 1) (Y 2 ) (Y 1 and Y 2 Is as previously defined), and z = 0, 1, 2), or a pharmaceutically acceptable salt thereof. |