| abstract |
(57) [Summary] [Structure] The following formula [Chemical formula 1] [In the formula, R represents a hydrogen atom, a hydroxyl group, a methyl group or a methylene group. However, when it has a hydroxyl group at the 17-position of the skeleton of the steroid, it also includes its acylated product, and when R is a hydroxyl group, its ketone compound is also included. ] The corticosteroid derivative represented by these, or its pharmacologically acceptable salt. [Effect] Since the corticosteroid derivative of the present invention is excellent in water solubility and has an antiallergic action, an antiinflammatory action, an antioxidant action, etc., it has various allergic and inflammatory diseases, as well as cataracts and various ischemic properties. It can be advantageously used for prevention and treatment of organ diseases. Further, the present compound is also useful as a UV absorbing component of cosmetics, a skin beautifying component and a stabilizing component of other cosmetic materials. |