| abstract |
(57) [Summary] (Modified) [Objective] To provide a novel kanamycin derivative having excellent antibacterial activity against various bacteria and a broad antibacterial spectrum, and having extremely low acute toxicity. [Structure] A compound represented by the general formula (I) and an acid addition salt thereof, an antibacterial composition containing the compound or a pharmaceutically acceptable acid addition salt thereof as an active ingredient, and the general formula (I) And the intermediate compounds that can be used in the production method. [In the formula, (i) R 1 = R 2 = R 3 = OH, and R 4 · R 5 = HF; (ii) R 1 = H, F, R 2 = R 5 = H, R 3 = R 4 = OH; (iii) R 1 = NH 2 in (a) R 2 = R 3 = R 4 = OH, R 5 = H, (b) R 2 = R 3 = OH, R 4 · R 5 = HF, (c) R 2 = H, R 3 = R 4 = OH, R 5 = H; and so on] |