| abstract |
(57) [Summary] [Structure] General formula [Chemical formula 1] [In the formula, R 1 is hydrogen, alkyl, benzyl, substituted benzyl, phenoxyalkyl and the like, R 2 is hydrogen, chlorine, hydroxyl group, alkyl, alkoxy, phenoxyalkoxy, (N-acetyl-N-hexyl) amino, R 3 , R 4 represents hydrogen and alkyl, and Het represents 5,6-dihydroimidazo [2,1-b] thiazol-3-yl, 5-ethoxycarbonyl-4-methyloxazol-2-yl and the like. ] The benzoxazin-3-one compound represented by these, or its salt. [Effects] PLA 2 inhibitory action, IL-1 production inhibitory action and carrageenin paw edema inhibitory action, allergic diseases such as atopic disease, various inflammatory diseases such as bronchial asthma, arthritis and pancreatitis, ischemic vascular disorder It is useful as a therapeutic and preventive agent for sepsis. |