| abstract |
(57) [Summary] [Object] To provide a substance which exhibits an inhibitory activity against an acylcoenzyme A cholesterol acyltransferase, and which is effective for the prevention and treatment of diseases caused by human cholesterol accumulation. [Structure] The following formula (1) (In the formula, R represents H or COCH 3 , and Y represents OH, O CHOCH 3 or O is shown, and X is O or N—CH 2. FO-3216 substance or a non-toxic salt thereof, which represents —CH 2 OH, and a double line of a dotted line and a solid line represents a single bond or a double bond. [Effects] This substance has an acylcoenzyme A cholesterol transferase inhibitory action. |