| abstract |
(57) [Summary] (Corrected) [Structure] Formula [I] (In the formula, R represents a hydrogen atom, an optionally substituted aryl group or aralkyl group, a cycloalkyl group, a cycloalkenyl group, an optionally substituted lower alkyl group or a tri-lower alkylsilyl group, and R 1 is A hydrogen atom or a carboxyl protecting group, and R 2 represents a hydroxyl group, a lower alkoxy group, an optionally protected amino group or an optionally protected alkylamino group) or a 2-alkynylmalonic acid derivative represented by An interleukin-1 production inhibitor comprising a salt. [Effect] It is expected to have an effect of suppressing the progression of the pathological conditions of rheumatoid arthritis and inflammatory diseases. |